Fish type I and type II interferons: composition, receptor usage, production and function
نویسندگان
چکیده
منابع مشابه
Production of type I interferons
Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The Peculiar Characteristics of Fish Type I Interferons
Antiviral type I interferons (IFNs) have been discovered in fish. Genomic studies revealed their considerable number in many species; some genes encode secreted and non-secreted isoforms. Based on cysteine motifs, fish type I IFNs fall in two subgroups, which use two different receptors. Mammalian type I IFN genes are intronless while type III have introns; in fish, all have introns, but struct...
متن کامل“Toll-free” pathways for production of type I interferons
Pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by different cellular pathogen recognition receptors (PRRs), which are expressed on cell membrane or in the cytoplasm of cells of the innate immune system. Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger pr...
متن کاملInduction of the pro-myelocytic leukaemia gene by type I and type II interferons.
The physiological role of the pro-myelocytic leukaemia (PML) gene product is poorly defined. Among other functions, PML is involved in haematopoietic differentiation and in control of cell growth and tumorigenesis. We investigated the regulation of human PML expression by interferons (IFNs) and IL-1 in various human haematopoietic lines (U937, THP1, HL60, NB4), in human diploid fibroblasts and ...
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ژورنال
عنوان ژورنال: Reviews in Aquaculture
سال: 2019
ISSN: 1753-5123,1753-5131
DOI: 10.1111/raq.12349